ABSTRACT
Introduction: Due to the high risk of Covid-19 disease, especially delta variant in pregnant women, as well as the novelty of this epidemic in the world and the lack of similar studies in Iran and the region, it seems necessary to perform a study on mortality rate and laboratory and clinical findings of the disease in pregnant women. Therefore, this study was performed aimed to determine the laboratory and clinical findings in hospitalized pregnant women with Covid -19 based on disease outcome during the outbreak of Delta variant (summer and autumn 2021) in Ardabil province. Methods: In this cross-sectional and descriptive study, all pregnant women with Covid-19 admitted to the hospitals of Ardabil province in summer and autumn 2021 at the time of delta outbreak were included. Finally, 187 infected pregnant mothers were studied. Demographic information, clinical signs and laboratory findings were studied in all mothers. Data were analyzed by SPSS (version 24) and Fisher Exact test and Pearson Correlation. P<0.05 was considered statistically significant. Results: Of the 187 infected pregnant women, 8 mothers died. Comorbidity was observed in 41 pregnant women. The most common clinical finding was shortness of breath (Dyspnea) and cough, and the most common laboratory finding was lymphopenia. Comparing the cured and dead mothers according to laboratory findings using Fisher's exact test showed that the difference between ALT (p <0.05), lactate dehydrogenase (p <0.001), AST (p <0.001), BS (P <0.05), creatinine (p <0.05) and total bilirubin (p <0.05) were statistically significant between the two groups. Conclusion: Infection to delta variant of Covid-19 disease resulted in 187 hospitalizations and 8 deaths of pregnant mothers in Ardabil province. Shortness of breath (Dyspnea) and cough were the most common clinical findings and lymphopenia was the most common laboratory finding.
ABSTRACT
Objective: To compare the clinical manifestations, liver function, and antibody levels between Omicron variant infection patients vaccinated and not vaccinated with COVID-19 vaccine. Methods: Totally 430 convalescent COVID-19 patients infected with Omicron variant in Tianjin were selected, including 150 patients vaccinated with Corona Vaccine(Sinovac group), 185 patients vaccinated with BBIBP-CorV(Beijing biological group), 41 patients vaccinated with Ad5-nCoV vaccine(CanSino group), 16 patients vaccinated with Anhui Zhifei, Changchun Bio, Lanzhou Bio, Shandong Bio, other adenovirus vector vaccines or mixed vaccination(other group), and 38 unvaccinated patients(unvaccinated group). The clinical manifestations, liver function indexes [alanine aminotransferase(ALT), aspartate aminotransferase(AST), total bilirubin(TB), albumin(ALB), total protein(TP), lactate dehydrogenase(LDH)], and antibody levels(IgG, IgM)were compared retrospectively. Results: There was no statistical difference in the sex composition ratio among groups(P > 0.05). The age of the Beijing biological group was significantly lower than that of other groups, and the proportion of time less than 3 months from the last vaccination to admission in the Beijing biological group and CanSino group was significantly higher than that in the Sinovac group and other groups(all P < 0.01). A total of 110 children aged less than 16 years were enrolled, including 7, 88, 0, 1 and 14 cases in the Sinovac group, Beijing biological group, CanSino group, other group, and unvaccinated group, respectively. There were 6 asymptomatic cases, 13 moderate cases, 91 mild cases and 0 severe case. There was no significant difference in the abnormal rate of ALT between Beijing biological group and unvaccinated group(P > 0.05), but the abnormal rates of ALT were higher in the Sinovac group and CanSino group than in the unvaccinated group and Beijing biological group(all P < 0.05). The abnormal rate of AST in the unvaccinated group was higher than that in other groups(P < 0.05). There were no significant differences in AST, TP or TB among the groups(all P > 0.05). The levels of ALT were higher in the Sinovac group and CanSino group than in Beijing biological Group and unvaccinated group, the level of ALB in the unvaccinated group was lower than that in the other groups, and the level of LDH in the Beijing biological group was higher than those in the Sinovac group and CanSino group(both P < 0.05). The IgG and IgM antibody levels of the unvaccinated group were significantly lower than those of the Sinovac group, Beijing biological group and CanSino group(all P < 0.05). Conclusions: Omicron variant infection patients vaccinated with BBIBP-CorV are younger and have a higher proportion of mild conditions, which can protect the liver function of patients to a certain extent. Patients vaccinated with different COVID-19 vaccines can produce higher levels of IgG and IgM antibodies than the unvaccinated patients.
ABSTRACT
Background: Tocilizumab (TCZ) is a new therapeutic alternative for severe cases of COVID-19 pneumonia. Aim: To evaluate the cumulative incidence (CI) of suspected adverse drug reactions (ADR) from TCZ in adult patients with COVID-19. Material and methods: An active pharmacological surveillance protocol was carried out in patients older than 18 years old, who received at least one dose of TCZ between May and August 2020 at a clinical hospital. Non-infectious ADRs were categorized according to the Common Terminology Criteria for Adverse Events and the development of infection was classified as present or absent. Causality and preventability of ADRs were determined with the Naranjo Algorithm and the modified Schumock & Thornton criteria, respectively. Results: The CI of ADRs caused by TCZ was 69.6% (95% confidence intervals (CI): 63.5-76.6). A rise in alanine and aspartate aminotransferases and the development of infections were the most frequent adverse events. Seventy-four percent were considered mild in severity. Sixty two percent of suspected non-infectious ADRs were classified as probable and all the infectious events as Possible. Of the ADRs observed, 33% were preventable. Conclusions: The occurrence of ADRs after the use of TCZ is frequent, of mild severity, and in one third of the cases, preventable. We suggest monitoring blood count, liver function tests and ruling out infection prior to TCZ administration.
ABSTRACT
Objective:In this study, to evaluate the clinical course and prognosis in COVID-19 patients, to evaluate the hematological and biochemical parameters at the time of admission to the hospital.
ABSTRACT
Objective: To analyze the epidemiological and clinical characteristics of foreign-imported patients infected with SARS-CoV-2 in Chengdu City.
ABSTRACT
Background: Coronavirus disease 19 (COVID-19) can have a severe presentation characterized by a dysregulated immune response requiring admission to the intensive care unit (ICU) [mmunomodula- tory treatments like tocilizumab were found to improve inflammatory markers and lung injury over time. We aim to evaluate the effectiveness of toeilizumab treatment 011 critically ill patients with severe COVID-19. Materials and methods: We conducted a multi-center retrospective cohort study of 154 adult patients admitted to the ICU for severe COVID-1 9 pneumonia between March 1 5 and May 8.2020. Data were obtained by electron- ic medical record (EMR) review. The primary outcome of interest was mortality.
ABSTRACT
Objective: We aimed to examine the effects of COVID-19 on biochemical and hematological parameters such as liver and kidney function tests, electrolyte levels and inflammatory markers.
ABSTRACT
Objective: The aim of this study is to investigate the clinical and laboratory features in confirmed COVID-19 patients without specific anti-SARS-CoV-2 antibody,it is important to interpret SARS-CoV-2 antibody test results correctly and provide effective management for COVID-19 patients without specific anti-SARS-CoV-2 antibody.
ABSTRACT
Objective: To investigate the clinical characteristics of corona virus disease 2019 (COVID-19) patients in Wuhan City, and the correlation between inflammatory factors and severity.
ABSTRACT
Objective: To investigate the clinical features of patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta variant infection and abnormal liver function in Guangdong Province, China.
ABSTRACT
Objective: To investigate the efficacy of entecavir (ETV) versus tenofovir disoproxil fumarate (TDF) and the treatment measures for poor response in previously untreated chronic hepatitis B (CHB) patients with high viral load.
ABSTRACT
Relevance. The Coronavirus pandemic, which has changed the lives of people and the medical community around the world, was announced by WHO in March 2020. The reason was the rapidly spreading new coronavirus infection SARS - CoV-2. It is important to know that in the future outbreaks of infections, crown-like or any other infections are not excluded and medical workers should be prepared to work in special conditions. The pandemic has not revealed a more severe course of the disease in pregnant women compared to the general population of adults, but medical workers need to be prepared for any development of the situation in case of changes in the epidemiological situation in the regions, the country and the world. The purpose of the study: analysis of the management of pregnancy and childbirth in patients infected with the COVID-19 virus in the mode of the infectious hospital of the Multidisciplinary City Hospital No. 3. Materials and methods research: A retrospective study was conducted based on the analysis of statistical data of 1541 medical records histories for the period from May to August 2021 in dynamics in the obstetric unit of the Multidisciplinary City Hospital No. 3 in Nur-Sultan. The inclusion criteria are pregnant patients with confirmed analysis of SARS - CoV-2 coronavirus infection. Clinical manifestations of COVID-19 coronavirus infection, laboratory, X-ray and CT data, timing and methods of delivery, severity and complications caused by this disease were taken for analysis in medical records. Quantitative data and percentage ratio are presented. Research results: 1501 (97.4%) hospitalized pregnant women had an average degree of CVI and a severe degree - 40 (2.6%). The following symptoms were most often noted: fever, cough, shortness of breath, diarrhea, sore throat, myalgia, chills. Less common: rash, headache, malaise and loss of appetite. Radiographs and CT data showed both typical bilateral signs of lung damage in 357 (30%) and unilateral signs in 618 (51.9%). Changes in laboratory parameters in these women included: an increase in the level of D-dimer, an increase in C-reactive protein, lymphocytopenia, a moderate increase in liver enzymes (aspartate aminotransferase, alanine aminotransferase), thrombocytopenia. Maternal mortality was not recorded during the study period. Conclusions: The management and treatment of pregnant women with coronavirus infection in MGB No. 3 in an infectious mode according to clinical protocols approved by the Joint Commission on the Quality of Medical Services of the Ministry of Health of the Republic of Kazakhstan allowed to improve pregnancy outcomes and prevent cases of maternal mortality. Further studies of the course of pregnancy and its outcomes in pregnant women with coronavirus infection are needed.